As with any injectable treatment that uses a needle, there can be some minor side-effects after a Profhilo® treatment. They can include some slight bruising, mild tenderness and some minor swelling. In very rare cases an allergic reaction, infection or nerve damage can be possible, but these instances are very few, as the hyaluronic acid used in Profhilo® is extremely pure and bio-compatible. Profhilo® also involves far fewer injections than many skin rejuvenation procedures for full face rejuvenation, so the side-effects are usually only very mild and subside very quickly.